Fosaprepitant impurity 55（R,S,R） CAS 1185503-00-7(free base)
| CAS No. | 1185503-00-7(free base) |
| Molecular Formula | C23H22F7N4O6P |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C23H22F7N4O6PC7H17NO5, Fosaprepitant impurity 55（R,S,R） contains a nitrogen-containing heterocyclic scaffold, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 809.63 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Fosaprepitant impurity 55（R,S,R） (CAS 1185503-00-7(free base), C23H22F7N4O6PC7H17NO5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Fosaprepitant impurity 55（R,S,R） meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H22F7N4O6P 2*C7H17NO5 |
| Molecular Weight | 809.63 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Fosaprepitant Standards
- Fosaprepitant Impurity 53 (CAS 1254261-32-9)
- Fosaprepitant Impurity 4 Dimeglumine (CAS 1523569-87-0)
- Fosaprepitant Impurity 19 (CAS 1623-07-0)
- Fosaprepitant Impurity 48 (CAS 1707-92-2)
- Fosaprepitant Impurity 6 (CAS 172822-01-4（free base）)
- Fosaprepitant Impurity 12 (CAS 2035475-10-4)
- Fosaprepitant Impurity 41 HCl (CAS 2377328-02-2)
- Fosaprepitant Impurity 17 (CAS 24021-90-7)
Recommended Standards
- Empagliflozin Impurity 302 (CAS CATO-C4X-1065302)
- Afatinib Impurity 9 (CAS CATO-C4X-10069)
- Pramipexole EP Impurity B (CAS 1246815-83-7)
- 1-(4-Ethylphenyl)-5-oxopyrrolidine-3-carboxamide (CAS 852410-96-9)
- 2-(2,6-Dimethylmorpholino)pyridin-3-amine (CAS 926271-27-4)
- 1-(5-(Furan-2-yl)thiophen-2-yl)ethan-1-amine (CAS 1706451-52-6)
- 893443-18-0 1-Ethyl-1-methylpyrrolidinium trifluoromethanesulfonate DTXSID9049372 (CAS 893443-18-0)
- 1-Methylpyridinium Chloride (CAS 7680-73-1)
- 4-(4,4-Difluoropiperidin-1-yl)-2-methoxyphenylamine (CAS 1233184-63-8)
- Pancreatic Polypeptide (1-17)-(Ala31,Aib32)-Neuropeptide Y (18-36) (human) trifluoroacetate salt (CAS 313988-70-4)
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